Barasertib (AZD1152-HQPA)
Names
[ CAS No. ]:
722544-51-6
[ Name ]:
Barasertib (AZD1152-HQPA)
[Synonym ]:
AZD1152-HQPA
INH 34
AZD-1152-HQPA
2-{3-[(7-{3-[Ethyl(2-hydroxyethyl)amino]propoxy}-4-quinazolinyl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide
Barasertib
2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide
1H-Pyrazole-5-acetamide, 3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-
AZD1152 HPQA
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Aurora B:0.37 nM (IC50)
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
796.7±60.0 °C at 760 mmHg
[ Molecular Formula ]:
C26H30FN7O3
[ Molecular Weight ]:
507.560
[ Flash Point ]:
435.6±32.9 °C
[ Exact Mass ]:
507.239410
[ PSA ]:
128.29000
[ LogP ]:
2.82
[ Appearance of Characters ]:
white to beige
[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C
[ Index of Refraction ]:
1.677
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
DMSO: >15mg/mL
MSDS
Safety Information
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Mol. Oncol. 9 , 1056-70, (2015)
The let-7 microRNA (miRNA) family has been implicated in the regulation of diverse cellular processes and disease pathogenesis. In cancer, loss-of-function of let-7 miRNAs has been linked to tumorigen...
The novel function of JADE1S in cytokinesis of epithelial cells.Cell Cycle 14 , 2821-34, (2015)
JADE1 belongs to a small family of PHD zinc finger proteins that interacts with histone acetyl transferase (HAT) HBO1 and is associated with chromatin. We recently reported JADE1 chromatin shuttling a...
Inhibitor of Aurora Kinase B Induces Differentially Cell Death and Polyploidy via DNA Damage Response Pathways in Neurological Malignancy: Shedding New Light on the Challenge of Resistance to AZD1152-HQPA.Mol. Neurobiol. 53 , 1808-23, (2016)
Aurora kinase B (AURKB), a crucial regulator of malignant mitosis, is involved in chromosome segregation and cytokinesis. AZD1152-HQPA is a selective inhibitor for AURKB activity and currently bears c...