PIPERMETHYSTINE

Names

[ Name ]:
PIPERMETHYSTINE

[Synonym ]:
(+/-)-5-acetoxy-5,6-dihydro-N-(1-oxo-3-phenylpropyl)-2(1H)-pyridone
Pipermethistin
2(1H)-Pyridinone,5-(acetyloxy)-5,6-dihydro-1-(1-oxo-3-phenylpropyl)
6-Oxo-1-(3-phenylpropanoyl)-1,2,3,6-tetrahydro-3-pyridinyl acetate
(+/-)-pipermethystine
5-acetoxy-1-(3-phenyl-propionyl)-5,6-dihydro-1H-pyridin-2-one

Biological Activity

[Description]:

Pipermethystine is an alkaloid that can be isolated from the Kava plant. Pipermethystine decreases HepG2 cell cellular ATP levels, mitochondrial membrane potential, and induces apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Nerurkar PV, et al. In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones. Toxicol Sci. 2004 May;79(1):106-11.

Chemical & Physical Properties

[ Density]:
1.23g/cm3

[ Boiling Point ]:
459.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₇NO₄

[ Molecular Weight ]:
287.31

[ Flash Point ]:
231.9ºC

[ Exact Mass ]:
287.11600

[ PSA ]:
63.68000

[ LogP ]:
1.41380

[ Index of Refraction ]:
1.574

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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