AG 1406

Names

[ Name ]:
AG 1406

[Synonym ]:
Propanedinitrile,[[4-hydroxy-3,5-bis(1-methylethyl)phenyl]methylene]
3,5-Diisopropyl-4-hydroxy-benzylidenmalonitril
AG 1406

Biological Activity

[Description]:

AG 1406 (compound M19) is a HER2 inhibitor, with an IC50 of 10.57 μM for HER2 in BT474 cell and >50 μM for EGFR in EGF-3T3 cell[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[References]

[1]. Hui Chen, et al. Methods and compositions for inhibiting cell proliferative disorders. Patent, US5789427A.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₈N₂O

[ Molecular Weight ]:
254.32700

[ Exact Mass ]:
254.14200

[ PSA ]:
67.81000

[ LogP ]:
4.06956

[ Storage condition ]:
-20℃

Related Compounds

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