71308-34-4

71308-34-4 structure

Name: AG 1406
Chemical Name: 2-[[4-hydroxy-3,5-di(propan-2-yl)phenyl]methylidene]propanedinitrile
CAS Number: 71308-34-4
Molecular Formula: C₁₆H₁₈N₂O
Molecular Weight: 254.32700
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2017-11-25 04:54:44
Modify Date: 2025-08-22 16:12:34
AG 1406 (compound M19) is a HER2 inhibitor, with an IC50 of 10.57 μM for HER2 in BT474 cell and >50 μM for EGFR in EGF-3T3 cell[1].

Name	2-[[4-hydroxy-3,5-di(propan-2-yl)phenyl]methylidene]propanedinitrile
Synonyms	Propanedinitrile,[[4-hydroxy-3,5-bis(1-methylethyl)phenyl]methylene] 3,5-Diisopropyl-4-hydroxy-benzylidenmalonitril AG 1406

Description	AG 1406 (compound M19) is a HER2 inhibitor, with an IC50 of 10.57 μM for HER2 in BT474 cell and >50 μM for EGFR in EGF-3T3 cell[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
References	[1]. Hui Chen, et al. Methods and compositions for inhibiting cell proliferative disorders. Patent, US5789427A.