(R)-Mephenytoin

Names

[ CAS No. ]:
71140-51-7

[ Name ]:
(R)-Mephenytoin

[Synonym ]:
(r)-(-)-mephenytoin

[Description]:

(R)-Mephenytoin ((-)-Mephenytoin), the R-enantiomer of Mephenytoin. Mephenytoin is an Anticonvulsant agent[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Neurological Disease

[In Vitro]

(R)-Mephenytoin can be N-demethylated by the cytochrome P450 (CYP) isoform CYP2C9 to form the metabolite 5-phenyl-5-ethylhydantoin (nirvanol)[1].

[References]

[ Density]:
1.154g/cm3

[ Melting Point ]:
137-138ºC

[ Molecular Formula ]:
C₁₂H₁₄N₂O₂

[ Molecular Weight ]:
218.25200

[ Exact Mass ]:
218.10600

[ PSA ]:
49.41000

[ LogP ]:
1.74020

[ Index of Refraction ]:
1.541

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport