R-γ-Decalactone

Names

[ CAS No. ]:
706-14-9

[ Name ]:
R-γ-Decalactone

[Synonym ]:
UNII:7HLS05KP9O
5-hexyldihydrofuran-2(3H)-one
EINECS 211-892-8
γ-Decalactone
MFCD00005404
2(3H)-Furanone, 5-hexyldihydro-
5-Hexyldihydro-2(3H)-furanone

Biological Activity

[Description]:

Gamma-decalactone, γ-decalactone is used as an essential food additive with a ruity peach flavor[1]. Ricinoleic acid (12-hydroxy-octadec-9-enoic acid) is used as the substrate in most production processes of γ-decalactone[2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Guan S, et al. Enhanced Biotransformation Productivity of Gamma-Decalactone from Ricinoleic Acid Based on the Expanded Vermiculite Delivery System. J Microbiol Biotechnol. 2019 Jul 28;29(7):1071-1077.

[2]. Pereira de Andrade D, et al. Production of γ-Decalactone by Yeast Strains under  Different Conditions. Food Technol Biotechnol. 2017 Jun;55(2):225-230.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
266.7±8.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₈O₂

[ Molecular Weight ]:
170.249

[ Flash Point ]:
105.8±15.9 °C

[ Exact Mass ]:
170.130676

[ PSA ]:
26.30000

[ LogP ]:
2.38

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.447

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU4600000

CHEMICAL NAME :: 2(3H)-Furanone, 5-hexyldihydro-

CAS REGISTRY NUMBER :: 706-14-9

BEILSTEIN REFERENCE NO. :: 0117547

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H18-O2

MOLECULAR WEIGHT :: 170.28

WISWESSER LINE NOTATION :: T5OVTJ E6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,741,1976 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02795 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6863 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LU4600000

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors.

J. Med. Chem. 48 , 3808-15, (2005)

The purpose of this study was to determine the cytochrome P450 1A2 (CYP1A2) inhibition potencies of structurally diverse compounds to create a comprehensive three-dimensional quantitative structure-ac...

Immobilization of Yarrowia lipolytica for aroma production from castor oil.

Appl. Biochem. Biotechnol. 169(7) , 2202-11, (2013)

The main aim of this study was to compare different materials for Y. lipolytica immobilization that could be used in the production of γ-decalactone (a peach-like aroma) in order to prevent the toxic ...

Surface properties of Yarrowia lipolytica and their relevance to gamma-decalactone formation from methyl ricinoleate.

Biotechnol. Lett. 27(6) , 417-22, (2005)

The surface of the lipid-degrading yeast, Yarrowia lipolytica, was characterized by contact angle and zeta potential (zeta) measurements. The cells were mainly hydrophilic with a negative charge that ...