Bis-Tos-PEG7

Names

[ Name ]:
Bis-Tos-PEG7

[Synonym ]:
heptaethylene glycol ditosylate
2-[2-(2-{2-[2-(2-{2-[(4-methylphenyl)sulfonyloxy]ethoxy}ethoxy)ethoxy]ethoxy}e thoxy)ethoxy]ethyl 4-methylbenzenesulfonate
3,6,9,12,15,18-Hexaoxaicosane-1,20-diyl bis(4-methylbenzenesulfonate)
1,20-bis(tosyloxy)-3,6,9,12,15,18-hexaoxaeicosane
Heptaethylene glycol di(p-toluenesulfonate)
3,6,9,12,15,18-hexaoxaeicosane-1,20-diol ditosylate

Biological Activity

[Description]:

Bis-Tos-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₄₂O₁₂S₂

[ Molecular Weight ]:
634.75600

[ Exact Mass ]:
634.21200

[ PSA ]:
158.88000

[ LogP ]:
4.67540

Safety Information

[ Hazard Codes ]:
Xn

Bis-Tos-PEG7

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds