EP4 receptor antagonist 4

Names

[ CAS No. ]:
691869-12-2

[ Name ]:
EP4 receptor antagonist 4

Biological Activity

[Description]:

EP4 receptor antagonist 4 is an EP4 receptor agonist with the human pEC50 value of 6.3[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[Target]

EP4:6.3 (pEC50)

[In Vitro]

EP4 receptor antagonist 4 (24 h) treatment shows agonism in HEK293 cells stably transfected with hEP4[1]. EP4 receptor antagonist 4 (30 min) treatment shows agonism (pEC50<5) and antagonism (pIC50<5)[1]. Cell Viability Assay[1] Cell Line: HEK293 cells Concentration: Incubation Time: 24 hours Result: Exhibited the human pEC50 value of 6.3.

[References]

[1]. Joannes Theodorus Maria Linders, et al. Bicyclic derivatives as ep4 agonists. WO2008092860A1

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₄N₂OS

[ Molecular Weight ]:
318.39

Related Compounds

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