Orexin receptor antagonist 4

Names

[ CAS No. ]:
2251017-69-1

[ Name ]:
Orexin receptor antagonist 4

Biological Activity

[Description]:

Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC50 of 295 nM) (WO2018206959A1; example 1)[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Orexin Receptor (OX Receptor)
Research Areas >> Neurological Disease

[Target]

OX2 Receptor:4.27 nM (IC50)

OX1 Receptor:295 nM (IC50)


[References]

[1]. David Sheppard, et al. Orexin receptor antagonists. WO2018206959A1

Chemical & Physical Properties

[ Molecular Formula ]:
C23H25FN4O2

[ Molecular Weight ]:
408.47

Related Compounds

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