Risperidone E-oxime

Names

[ Name ]:
Risperidone E-oxime

[Synonym ]:
4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-[(E)-(2,4-difluorophenyl)(hydroxyimino)methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-
3-(2-{4-[(E)-(2,4-Difluorophenyl)(hydroxyimino)methyl]-1-piperidinyl}ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

Biological Activity

[Description]:

Risperidone E-oxime is an impurity of Risperidone[1]. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively [2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Pavel Slanina, et al. Process for making risperidone and intermediates therefor. US20040097523A1.

[2]. Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl). 1993;110(3):265-72.

[3]. Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32(4):757-64.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
569.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₈F₂N₄O₂

[ Molecular Weight ]:
430.491

[ Flash Point ]:
297.9±32.9 °C

[ Exact Mass ]:
430.218048

[ PSA ]:
79.68000

[ LogP ]:
3.16

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.631

[ Storage condition ]:
2-8℃

Risperidone E-oxime

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds