Suc-Gly-Gly-Phe-pNA

Names

[ Name ]:
Suc-Gly-Gly-Phe-pNA

[Synonym ]:
4-[[2-[[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-oxobutanoic acid
Suc-Gly-Gly-Phe-pNA

Biological Activity

[Description]:

Suc-Gly-Gly-Phe-pNA is the chymotrypsin substrate with an Km value of 1.6 mM[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

[References]

[1]. Tanaka T, et al. Substrate Specificity of Aqualysin I, a Bacterial Thermophilic Alkaline Serine Protease from Thermus aquaticus YT-1: Comparison with Proteinase K, Subtilisin BPN' and Subtilisin Carlsberg. Biosci Biotechnol Biochem. 1998;62(11):2161-5.

[2]. Pourzand C, et al. Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: the role of ferritin. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6751-6.

Chemical & Physical Properties

[ Density]:
1.401g/cm3

[ Boiling Point ]:
1005.6ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₅N₅O₈

[ Molecular Weight ]:
499.47300

[ Flash Point ]:
562ºC

[ Exact Mass ]:
499.17000

[ PSA ]:
199.52000

[ LogP ]:
2.12690

[ Index of Refraction ]:
1.622

[ Storage condition ]:
20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

New proteolytic enzymes in yeast.

Arch. Biochem. Biophys. 207 , 445, (1981)

Noncovalent modification of chymotrypsin surface using an amphiphilic polymer scaffold: implications in modulating protein function.

J. Am. Chem. Soc. 127(30) , 10693-8, (2005)

We report here on a new amphiphilic homopolymer that binds noncovalently to proteins. This polymer not only binds to the target protein chymotrypsin with submicromolar affinity but also stabilizes the...

Related Compounds

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