Z-Gly-Gly-Phe-chloromethylketone

Names

[ Name ]:
Z-Gly-Gly-Phe-chloromethylketone

[Synonym ]:
Z-Gly-Gly-Phe chloromethyl ketone
Z-Gly-Gly-Phe-chloromethylketone

Biological Activity

[Description]:

Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC50 value of 125 μM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

[References]

[1]. Moreira W, et, al. Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome. Front Microbiol. 2017 Apr 27;8:746.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₄ClN₃O₅

[ Molecular Weight ]:
445.90

[ Exact Mass ]:
445.14000

[ PSA ]:
113.60000

[ LogP ]:
2.73710

Z-Gly-Gly-Phe-chloromethylketone

Names

Biological Activity

Chemical & Physical Properties

Related Compounds