SKF 91488 dihydrochloride

Names

[ Name ]:
SKF 91488 dihydrochloride

[Synonym ]:
S-(4-dimethylamino-butyl)-isothiourea, dihydrochloride
S-(4-Dimethylamino-butyl)-isothioharnstoff, Dihydrochlorid
S-[4-(dimethylamino)butyl]isothiourea dihydrochloride

Biological Activity

[Description]:

SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 microM. SKF 91488 dihydrochloride inhibits the methylation of labeled histamine in mice[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

Research Areas >> Neurological Disease

[References]

[1]. Beaven MA, et, al. Inhibition of histamine methylation in vivo by the dimaprit analog, SKF Compound 91488. Agents Actions. 1979 Dec;9(5-6):455-60.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₁₉Cl₂N₃S

[ Molecular Weight ]:
248.22

[ Exact Mass ]:
211.09100

[ PSA ]:
78.41000

[ LogP ]:
2.55690

Related Compounds

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