PDM 2

Names

[ Name ]:
PDM 2

[Synonym ]:
1,3-Dichloro-5-[(E)-2-(4-chlorophenyl)vinyl]benzene
1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene
Benzene, 1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]-
PDM 2

Biological Activity

[Description]:

PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor

Research Areas >> Inflammation/Immunology

[Target]

Ki: 1.2±0.4 nM(AhR)[1]

[In Vitro]

PDM2 (Compound 4b) exhibits a Ki of 1.2±0.4 nM for AhR and no affinity for estrogen receptor (ER), confirming that replacement of hydroxyl with chloride abolished binding on ER and increased dramatically the affinity for AhR[1].

[References]

[1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
394.2±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₉Cl₃

[ Molecular Weight ]:
283.580

[ Flash Point ]:
276.5±23.5 °C

[ Exact Mass ]:
281.976990

[ LogP ]:
6.58

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.675

[ Storage condition ]:
2-8℃

PDM 2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds