688348-25-6

688348-25-6 structure

Name: PDM 2
Chemical Name: 1,3-dichloro-5-[2-(4-chlorophenyl)ethenyl]benzene
CAS Number: 688348-25-6
Molecular Formula: C₁₄H₉Cl₃
Molecular Weight: 283.580
Catalog: Signaling Pathways Immunology/Inflammation Aryl Hydrocarbon Receptor
Create Date: 2016-07-10 00:28:09
Modify Date: 2025-08-25 10:27:53
PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM.

Name	1,3-dichloro-5-[2-(4-chlorophenyl)ethenyl]benzene
Synonyms	1,3-Dichloro-5-[(E)-2-(4-chlorophenyl)vinyl]benzene 1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene Benzene, 1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]- PDM 2

Description	PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Research Areas >> Inflammation/Immunology
Target	Ki: 1.2±0.4 nM(AhR)[1]
In Vitro	PDM2 (Compound 4b) exhibits a Ki of 1.2±0.4 nM for AhR and no affinity for estrogen receptor (ER), confirming that replacement of hydroxyl with chloride abolished binding on ER and increased dramatically the affinity for AhR[1].
References	[1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91.