Loxoprofen

Names

[ Name ]:
Loxoprofen

[Synonym ]:
IOXOPROFEN
MFCD00864331
KOLOXO
Benzeneacetic acid, α-methyl-4-[(2-oxocyclopentyl)methyl]-
2-{4-[(2-Oxocyclopentyl)methyl]phenyl}propanoic acid
Loxoprofen

Biological Activity

[Description]:

Loxoprofen is a non-steroidal anti-inflammatory drug.Target: COXLoxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. Loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

COX-1:6.5 μM (IC50, in human whole blood)

COX-2:13.5 μM (IC50, in human whole blood)

[References]

[1]. Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1201-3.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
417.9±20.0 °C at 760 mmHg

[ Melting Point ]:
108.5 - 111ºC

[ Molecular Formula ]:
C₁₅H₁₈O₃

[ Molecular Weight ]:
246.302

[ Flash Point ]:
220.7±18.3 °C

[ Exact Mass ]:
246.125595

[ PSA ]:
54.37000

[ LogP ]:
1.87

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.568

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Determination of nonsteroidal anti-inflammatory drugs in human tear and plasma samples using ultra-fast liquid chromatography-tandem mass spectrometry.

Jpn. J. Ophthalmol. 59 , 364-71, (2015)

To evaluate a new rapid and sensitive method for analyzing human tears and plasma for nonsteroidal anti-inflammatory drugs (NSAIDs) and investigate the influence of the transfer of NSAIDs in an ocular...

Risk of peptic ulcer bleeding associated with Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, low-dose aspirin, and antihypertensive drugs: a case-control study.

J. Gastroenterol. Hepatol. 30(2) , 292-8, (2015)

The associations between antithrombotic or antihypertensive drugs and peptic ulcer bleeding (PUB) remain unknown, particularly in Asia, where Helicobacter pylori infection is prevalent. This study aim...

Effect of X-ray exposure on the pharmaceutical quality of drug tablets using X-ray inspection equipment.

Drug Dev. Ind. Pharm. 41 , 953-8, (2015)

X-ray inspection equipment is widely used to detect missing materials and defective goods in opaque containers. Its application has been expanded to the pharmaceutical industry to detect the presence ...