Sanguisorbigenin

Names

[ Name ]:
Sanguisorbigenin

[Synonym ]:
(6aS,12bR)-10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-3,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-hexadecahydro-4H-picene-4a-carboxylic acid

Biological Activity

[Description]:

Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistant S. aureus (MRSA)[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL[1]. The expression of blaR1, mecA and blaZ is significantly inhibited in MRSA in a dose-dependent manner when it is treated with sub-MIC (1.56-6.25 μg/mL) concentrations of Sanguisorbigenin. Sanguisorbigenin remarkably reduces the gene expression of mecA. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decrease PBP2a expression[1].

[References]

[1]. S Wang, et al. Antibacterial activity and synergy of antibiotics with sanguisorbigenin isolated from Sanguisorba officinalis L. against methicillin-resistant Staphylococcus aureus. Lett Appl Microbiol. 2021 Mar;72(3):238-244.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₄₆O₃

[ Molecular Weight ]:
454.68400

[ Exact Mass ]:
454.34500

[ PSA ]:
57.53000

[ LogP ]:
7.15370

Related Compounds

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