6812-98-2

6812-98-2 structure

Name: Sanguisorbigenin
Chemical Name: 19-Dehydroursolsaeure
CAS Number: 6812-98-2
Molecular Formula: C₃₀H₄₆O₃
Molecular Weight: 454.68400
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-01-30 16:35:59
Modify Date: 2025-08-27 17:50:32
Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistant S. aureus (MRSA)[1].

Name	19-Dehydroursolsaeure
Synonyms	(6aS,12bR)-10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-3,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-hexadecahydro-4H-picene-4a-carboxylic acid

Description	Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistant S. aureus (MRSA)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL[1]. The expression of blaR1, mecA and blaZ is significantly inhibited in MRSA in a dose-dependent manner when it is treated with sub-MIC (1.56-6.25 μg/mL) concentrations of Sanguisorbigenin. Sanguisorbigenin remarkably reduces the gene expression of mecA. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decrease PBP2a expression[1].
References	[1]. S Wang, et al. Antibacterial activity and synergy of antibiotics with sanguisorbigenin isolated from Sanguisorba officinalis L. against methicillin-resistant Staphylococcus aureus. Lett Appl Microbiol. 2021 Mar;72(3):238-244.