Alclometasone

Names

[ Name ]:
Alclometasone

[Synonym ]:
(7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
alcometasone
136H45TB7B
7alpha-Chloro-16alpha-methylprednisolone
UNII-136H45TB7B
Alclomethasone
Aclometasone

Biological Activity

[Description]:

Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[Target]

IC50: glucocorticoid receptor[1]

[In Vivo]

The prodrug of alclometasone is alclometasone dipropionate[2].Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice[2].

[References]

[1]. Alclometasone

[2]. Nishibe Y, et al. Species and sex differences in the inhibitory action of the corticosteroid alclometasone dipropionate on the hepatic drug-metabolizing system.Jpn J Pharmacol. 1989 Aug;50(4):435-43.

Chemical & Physical Properties

[ Density]:
1.34g/cm3

[ Boiling Point ]:
607.1ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₉ClO₅

[ Molecular Weight ]:
408.91600

[ Flash Point ]:
320.9ºC

[ Exact Mass ]:
408.17000

[ PSA ]:
94.83000

[ LogP ]:
2.02090

[ Index of Refraction ]:
1.607

Safety Information

[ HS Code ]:
2942000000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2942000000