67452-97-5
67452-97-5 structure
- Name: Alclometasone
- Chemical Name: alclometasone
- CAS Number: 67452-97-5
- Molecular Formula: C22H29ClO5
- Molecular Weight: 408.91600
- Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
- Create Date: 2018-06-22 18:37:06
- Modify Date: 2025-08-25 21:15:08
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Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis[1].
| Name | alclometasone |
|---|---|
| Synonyms |
(7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
alcometasone 136H45TB7B 7alpha-Chloro-16alpha-methylprednisolone UNII-136H45TB7B Alclomethasone Aclometasone |
| Description | Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: glucocorticoid receptor[1] |
| In Vivo | The prodrug of alclometasone is alclometasone dipropionate[2].Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice[2]. |
| References |
[1]. Alclometasone |
| Density | 1.34g/cm3 |
|---|---|
| Boiling Point | 607.1ºC at 760mmHg |
| Molecular Formula | C22H29ClO5 |
| Molecular Weight | 408.91600 |
| Flash Point | 320.9ºC |
| Exact Mass | 408.17000 |
| PSA | 94.83000 |
| LogP | 2.02090 |
| Index of Refraction | 1.607 |
| HS Code | 2942000000 |
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| Precursor 1 | |
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| DownStream 0 | |
| HS Code | 2942000000 |
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