2-Hydroxy-4-methoxybenzaldehyde

Names

[ CAS No. ]:
673-22-3

[ Name ]:
2-Hydroxy-4-methoxybenzaldehyde

[Synonym ]:
o-Hydroxy-p-methoxybenzaldehyde
VHR BQ DO1
2-HO-4-MeO-C6H3CHO
2-Hydroxy-4-methoxybenzaldehyde
4-Methoxysalicylaldehyde
4-Methoxysalicyaldehyde
Salicylaldehyde, 4-methoxy-
Benzaldehyde,2-hydroxy-4-methoxy
2-Hydroxy-p-anisaldehyde
Benzaldehyde, 2-hydroxy-4-methoxy-
p-Anisaldehyde,2-hydroxy
2-hydroxy-4-methoxy benzaldehyde
4-methoxy-salicylaldehyde
Salicylaldehyde,4-methoxy
EINECS 211-604-0
4-methoxy-2-hydroxybenzaldehyde
MFCD00003327
p-Anisaldehyde, 2-hydroxy-

Biological Activity

[Description]:

2-Hydroxy-4-methoxybenzaldehyde, a chemical compound and an isomer of Vanillin, could be used to synthesis Urolithin M7[1]. 2-hydroxy-4-methoxybenzaldehyde is a potent tyrosinase inhibitor from three East African medicinal plants, Mondia whitei, Rhus vulgaris Meikle, and Sclerocarya caffra Sond[2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[Target]

Tyrosinase[2].

[References]

[1]. Bodwell Graham, et al. An Inverse Electron-Demand Diels-Alder-Based Total Synthesis of Urolithin M7. Synlett. 2011 (15): 2245.

[2]. Kubo I, et al. 2-Hydroxy-4-methoxybenzaldehyde: a potent tyrosinase inhibitor from African medicinal plants. Planta Med. 1999 Feb;65(1):19-22.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
271.5±20.0 °C at 760 mmHg

[ Melting Point ]:
41-43 °C(lit.)

[ Molecular Formula ]:
C₈H₈O₃

[ Molecular Weight ]:
152.15

[ Flash Point ]:
112.1±15.3 °C

[ Exact Mass ]:
152.047348

[ PSA ]:
46.53000

[ LogP ]:
1.79

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.588

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ2810000

CHEMICAL NAME :: p-Anisaldehyde, 2-hydroxy-

CAS REGISTRY NUMBER :: 673-22-3

BEILSTEIN REFERENCE NO. :: 1072443

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 500 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,17,1988

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
BZ2810000

[ HS Code ]:
29124900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2912499000

[ Summary ]:
2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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