Ansamitocin P-3

Names

[ Name ]:
Ansamitocin P-3

[Synonym ]:
maytansinol 3-butyrate
Propanoic acid, 2-methyl-, (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10,12,1 4(26),16,18-pentaen-6-yl ester
C32H43ClN2O9
Maytansinol butyrate
(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2- methylpropanoate
Ansamitocin P-3
MFCD00274586
Ansamitocin P 3'

Biological Activity

[Description]:

Ansamitocin P 3' exhibits antitumour activity, is an antibody drug conjugate cytotoxin. The more information please refer to Ansamitocin P-3 (HY-15739).

[Related Catalog]:

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

Research Areas >> Cancer

[References]

[1]. Venghateri JB, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site. PLoS One. 2013 Oct 4;8(10):e75182.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
833.1±65.0 °C at 760 mmHg

[ Melting Point ]:
182-185℃

[ Molecular Formula ]:
C₃₂H₄₃ClN₂O₉

[ Molecular Weight ]:
635.145

[ Flash Point ]:
457.7±34.3 °C

[ Exact Mass ]:
634.265686

[ PSA ]:
136.16000

[ LogP ]:
5.09

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.583

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OQ2293000

CHEMICAL NAME :: Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, butyrate (ester)

CAS REGISTRY NUMBER :: 66547-09-9

LAST UPDATED :: 199401

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C32-H43-Cl-N2-O9

MOLECULAR WEIGHT :: 635.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-130495

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/22;R36/37/38

[ Safety Phrases ]:
S26;S36

[ WGK Germany ]:
3

[ RTECS ]:
OQ2293000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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