ANSAMITOCIN P-4
Names
[ CAS No. ]:
66547-10-2
[ Name ]:
ANSAMITOCIN P-4
[Synonym ]:
Tam 340
ansamitocin P-4
Maytansinol isovalerate
Chemical & Physical Properties
[ Density]:
1.28g/cm3
[ Boiling Point ]:
838.7ºC at 760 mmHg
[ Molecular Formula ]:
C33H45ClN2O9
[ Molecular Weight ]:
649.17100
[ Flash Point ]:
461ºC
[ Exact Mass ]:
648.28100
[ PSA ]:
136.16000
[ LogP ]:
5.10750
[ Index of Refraction ]:
1.58
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OQ2295000
- CHEMICAL NAME :
- Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, isovalerate (ester)
- CAS REGISTRY NUMBER :
- 66547-10-2
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C33-H45-Cl-N2-O9
- MOLECULAR WEIGHT :
- 649.25
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 625 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 4 ug/kg
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,1707,1980