Arterolane
Names
Biological Activity
[Description]:
Arterolane is an antimalarial agent, with IC50 of both 1.1 nM against P. falciparum Ro73 and W2, respectively.
[Related Catalog]:
[Target]
IC50: 1.1 nM (P. falciparum Ro73), 1.1 nM (P. falciparum W2)[1]
[In Vitro]
Arterolane (Trioxolane 7; OZ277; RBx-11160) is an antimalarial agent, with IC50s of both 1.1 nM (0.43 ng/mL) against P. falciparum Ro73 and W2, respectively. Arterolane also shows inhibitory activity against several other P. falciparums, with IC50s of 1.0, 1.6, 0.90, 0.91, 1.4, 1.5, 0.83, and 0.84 ng/mL for P. falciparum K1, Fc27, FVO, NF54, HB3, FCB1, ITG2-F6, and MAD20, respectively[1].
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.202 g/cm3
[ Boiling Point ]:
572.161ºC at 760 mmHg
[ Molecular Formula ]:
C22H36N2O4
[ Molecular Weight ]:
392.53200
[ Flash Point ]:
299.832ºC
[ Exact Mass ]:
392.26800
[ PSA ]:
86.30000
[ LogP ]:
4.78790
[ Storage condition ]:
2-8℃