664338-39-0

664338-39-0 structure

Name: Arterolane
Chemical Name: Arterolane
CAS Number: 664338-39-0
Molecular Formula: C₂₂H₃₆N₂O₄
Molecular Weight: 392.53200
Catalog: Signaling Pathways Anti-infection Parasite
Create Date: 2017-03-01 04:19:43
Modify Date: 2024-01-03 11:37:24
Arterolane is an antimalarial agent, with IC50 of both 1.1 nM against P. falciparum Ro73 and W2, respectively.

Name	Arterolane
Synonyms	oz277 unii-3n1tn351vb

Description	Arterolane is an antimalarial agent, with IC50 of both 1.1 nM against P. falciparum Ro73 and W2, respectively.
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
Target	IC50: 1.1 nM (P. falciparum Ro73), 1.1 nM (P. falciparum W2)[1]
In Vitro	Arterolane (Trioxolane 7; OZ277; RBx-11160) is an antimalarial agent, with IC50s of both 1.1 nM (0.43 ng/mL) against P. falciparum Ro73 and W2, respectively. Arterolane also shows inhibitory activity against several other P. falciparums, with IC50s of 1.0, 1.6, 0.90, 0.91, 1.4, 1.5, 0.83, and 0.84 ng/mL for P. falciparum K1, Fc27, FVO, NF54, HB3, FCB1, ITG2-F6, and MAD20, respectively[1].
References	[1]. Vennerstrom JL, et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature. 2004 Aug 19;430(7002):900-4.