Pergolide

Names

[ Name ]:
Pergolide

[Synonym ]:
pergolida
(6aR,9R,10aR)-9-[(methylsulfanyl)methyl]-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline
Permax (TN)
(8b)-8-[(Methylthio)methyl]-6-propylergoline
Pergolidum [INN-Latin]
(6aR,9R,10aR)-9-(Methylthiomethyl)-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline
D-6-n-Propyl-8b-methylmercaptomethylergoline
Ly 141B
(6aR,9R,10aR)-9-[(Methylsulfanyl)methyl]-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]chinolin
8β-[(Methylthio)methyl]-6-propylergoline
Permax
Ergoline, 8-[(methylthio)methyl]-6-propyl-, (8β)-
Pergolide
Pergolidum
Pergolida [INN-Spanish]
(6aR,9R,10aR)-9-(methylsulfanylmethyl)-7-propyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline
Ergoline, 8-((methylthio)methyl)-6-propyl-, (8β)-
UNII-24MJ822NZ9
Pergolide (INN)
(8β)-8-[(methylthio)methyl]-6-propylergoline
(8β)-8-[(Methylsulfanyl)methyl]-6-propylergoline

Biological Activity

[Description]:

Pergolide (LY127809 (free base)) is an ergot-derived orally active dopamine receptor agonist. Pergolide can be used for Parkinson disease research[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Van Camp G, et al. Treatment of Parkinson's disease with pergolide and relation to restrictive valvular heart disease. Lancet. 2004 Apr 10;363(9416):1179-83.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
491.3±35.0 °C at 760 mmHg

[ Melting Point ]:
207.5ºC

[ Molecular Formula ]:
C₁₉H₂₆N₂S

[ Molecular Weight ]:
314.488

[ Flash Point ]:
250.9±25.9 °C

[ Exact Mass ]:
314.181671

[ PSA ]:
44.33000

[ LogP ]:
4.49

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.614

Safety Information

[ RIDADR ]:
UN 1544 6.1/PG II

[ RTECS ]:
KE6344964

[ Packaging Group ]:
II

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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