6-Demethoxytangeretin

Names

[ Name ]:
6-Demethoxytangeretin

[Synonym ]:
6-Demethoxytangeretin
4',5,7,8-Tetramethoxyflavone
5,7,8-Trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-(4-methoxyphenyl)-
5,7,8,4'-tetramethoxyflavone
UNII-2U2U884D0P
6-Demethoxytangeritin
Tetra-O-methylisoscutellarein
tetramethyl-o-isoscutellarein

Biological Activity

[Description]:

6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways[1]. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons[2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[References]

[1]. Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5.

[2]. Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409.

Chemical & Physical Properties

[ Density]:
1.243±0.06 g/cm3

[ Boiling Point ]:
536.9±50.0 °C at 760 mmHg

[ Melting Point ]:
216-217 ºC

[ Molecular Formula ]:
C₁₉H₁₈O₆

[ Molecular Weight ]:
342.343

[ Flash Point ]:
237.5±30.2 °C

[ Exact Mass ]:
342.110352

[ PSA ]:
67.13000

[ LogP ]:
3.06

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.575

[ Storage condition ]:
2-8℃

[ Water Solubility ]:
Practically insoluble (0.027 g/L) (25 ºC)

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%