1-Oxo Ibuprofen

Names

[ Name ]:
1-Oxo Ibuprofen

[Synonym ]:
2-[4-(2-methylpropanoyl)phenyl]propanoic acid

Biological Activity

[Description]:

1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. YongFang Rao, et al. Degradation of ibuprofen by a synergistic UV/Fe(III)/Oxone process. Chemical Engineering Journal. Volume 283, 1 January 2016, Pages 65-75.

[2]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.

Chemical & Physical Properties

[ Density]:
1.107g/cm3

[ Boiling Point ]:
377.952ºC at 760 mmHg

[ Melting Point ]:
85-87ºC

[ Molecular Formula ]:
C₁₃H₁₆O₃

[ Molecular Weight ]:
220.26400

[ Flash Point ]:
196.555ºC

[ Exact Mass ]:
220.11000

[ PSA ]:
54.37000

[ LogP ]:
2.71340

[ Index of Refraction ]:
1.528

[ Storage condition ]:
-20°C Freezer

MSDS

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Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2918300090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%