Isosorbide

Names

[ CAS No. ]:
652-67-5

[ Name ]:
Isosorbide

[Synonym ]:
(3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furane-3,6-diol
Isosorbid
EINECS 211-492-3
D-Glucitol, 1,4:3,6-dianhydro-
D-Isosorbide
dianhydro-D-sorbitol
Isosorbide
dianhydro-D-glucitol
L-Glucitol, 1,4:3,6-dianhydro-
hydronol
1,4:3,6-Dianhydro-D-glucitol
D-1,4:3,6-Dianhydroglucitol
MFCD00064827
at101
1,4:3,6-dianhydrogluticol
IsMotic
(3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol
isobide
1,4:3,6-dianhydro-D-sorbitol
devicoran
1,4:3,6-Dianhydro-L-glucitol

Biological Activity

[Description]:

Isosorbide is used as a diuretic used mainly to treat hydrocephalus and is also used to treat glaucoma.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Cardiovascular Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
372.1±42.0 °C at 760 mmHg

[ Melting Point ]:
60-63 °C(lit.)

[ Molecular Formula ]:
C₆H₁₀O₄

[ Molecular Weight ]:
146.141

[ Flash Point ]:
178.8±27.9 °C

[ Exact Mass ]:
146.057907

[ PSA ]:
58.92000

[ LogP ]:
-1.75

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.562

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4380000

CAS REGISTRY NUMBER :: 652-67-5

BEILSTEIN REFERENCE NO. :: 0080510

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H10-O4

MOLECULAR WEIGHT :: 146.16

WISWESSER LINE NOTATION :: L44TJ BQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,15,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64(4),158S,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 289 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,187,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,71,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6870 mg/kg

TOXIC EFFECTS :: Brain and Coverings - changes in cerebral spinal fluid

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,15,1969

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S24/25

[ WGK Germany ]:
2

[ RTECS ]:
LZ4380000

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%