UNII:CC64495H41

Names

[ Name ]:
UNII:CC64495H41

[Synonym ]:
7-monohydroxyflavanone
7-hydroxy-2-phenyl-4-chromanone
MFCD00017487
7-Hydroxyflavanone,7-Hydroxy-2-phenylchroman-4-one
7-hydroxy-flavanone
7-HYDROXY-2-PHENYL-CHROMAN-4-ONE
7-HYDROXY-2-PHENYLCHROMAN-4-ONE
4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-phenyl-
7-hydroxyflavan-4-one
UNII:CC64495H41
7-HYDROXYFLAVANONE
HYDROXYFLAVANONE,7
7-Hydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one

Biological Activity

[Description]:

7-Hydroxyflavanone is an aromatase (cytochrome P450 19; CYP19) inhibitor with an IC50 of 65 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Aromatase

[Target]

IC50: 65 μM (Aromatase)[1]

[References]

[1]. Sanderson JT, et al. Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2004 Nov;82(1):70-9.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
464.3±45.0 °C at 760 mmHg

[ Melting Point ]:
188-190 °C(lit.)

[ Molecular Formula ]:
C₁₅H₁₂O₃

[ Molecular Weight ]:
240.254

[ Flash Point ]:
181.2±22.2 °C

[ Exact Mass ]:
240.078644

[ PSA ]:
46.53000

[ LogP ]:
3.49

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.632

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%