7-Hydroxyflavone

Names

[ Name ]:
7-Hydroxyflavone

[Synonym ]:
7-hydroxy-2-phenylchromen-4-one
7-Hydroxy-2-phenyl-4H-chromen-4-one
7-Hydroxyflavone
4H-1-Benzopyran-4-one, 7-hydroxy-2-phenyl-
EINECS 229-705-3
7--Hydroxy-2-phenyl-4-benzopyrone
MFCD00006835

Biological Activity

[Description]:

7-Hydroxyflavone is a flavonoid isolated from M. indica, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Vinutha K, et al. Aqueous extract from Madhuca indica bark protects cells from oxidative stress caused by electron beam radiation: in vitro, in vivo and in silico approach. Heliyon. 2019 May 30;5(5):e01749.

[2]. Sengupta B, et al. Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cells. PLoS One. 2017 Jun 22;12(6):e0179777.

[3]. Sengupta B, et al. Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cells. PLoS One. 2017 Jun 22;12(6):e0179777.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
450.1±45.0 °C at 760 mmHg

[ Melting Point ]:
245-247 °C(lit.)

[ Molecular Formula ]:
C₁₅H₁₀O₃

[ Molecular Weight ]:
238.238

[ Flash Point ]:
176.3±22.2 °C

[ Exact Mass ]:
238.062988

[ PSA ]:
50.44000

[ LogP ]:
3.32

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.666

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ WGK Germany ]:
3

[ HS Code ]:
2914400090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%