N-acetyl-L-methionine

Names

[ CAS No. ]:
65-82-7

[ Name ]:
N-acetyl-L-methionine

[Synonym ]:
EINECS 200-617-7
MFCD00064441
N-Acetyl-L-methionine
N-acetyl-methionine
Thiomedon
L-Methionine, N-acetyl-
(2S)-2-acetamido-4-methylsulfanylbutanoic acid
Acetylmethionine
Methionine, N-acetyl-, L-
Methionamine
L-N-Acetyl-Methionine
L-(N-Acetyl)methionine
Ac-Met-OH

Biological Activity

[Description]:

N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Ball RO, et al. The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans. J Nutr. 2006 Jun;136(6 Suppl):1682S-1693S.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
371.3±52.0 °C at 760 mmHg

[ Melting Point ]:
104-107ºC

[ Molecular Formula ]:
C₇H₁₃NO₃S

[ Molecular Weight ]:
191.248

[ Flash Point ]:
178.3±30.7 °C

[ Exact Mass ]:
191.061615

[ PSA ]:
91.70000

[ LogP ]:
0.95

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.532

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PD0480000

CHEMICAL NAME :: Methionine, N-acetyl-

CAS REGISTRY NUMBER :: 65-82-7

BEILSTEIN REFERENCE NO. :: 1725552

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H13-N-O3-S

MOLECULAR WEIGHT :: 191.27

WISWESSER LINE NOTATION :: 1VMYVQ2S1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 435 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,262,1970

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
PD0480000

[ HS Code ]:
29309070

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29309070

Articles

Importance of product inhibition in the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry.

Anal. Biochem. 308 , 285-293, (2002)

The hydrolysis of N-acetyl-L-methionine, N-acetylglycine, N-acetyl-L-phenylalanine, and N-acetyl-L-alanine at 298.35K by porcine kidney acylase I (EC 3.5.1.14) was monitored by the heat released upon ...

Model sclerotization studies. 4. Generation of N-acetylmethionyl catechol adducts during tyrosinase-catalyzed oxidation of catechols in the presence of N-acetylmethionine.

Arch. Insect Biochem. Physiol. 38(1) , 44-52, (1998)

Incubation of catechol with mushroom tyrosinase in the presence of N-acetylmethionine resulted in the generation of an adduct. This product was identified to be N-acetylmethionyl catechol, on the basi...

Identification of N-acetylmethionine as the product released during the NH2-terminal processing of a pseudo-class I actin.

J. Biol. Chem. 264(19) , 11491-6, (1989)

Genes for the various isoactins define two classes of actin. Class I actin genes code for Met-Asp(Glu)-actin, and class II actin genes code for Met-X-Asp(Glu)-actin where X is usually cysteine. Amino ...

Related Compounds

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