Eperisone

Names

[ Name ]:
Eperisone

[Synonym ]:
4-ethylphenyl-2-methyl-3-piperidinopropiopenone
4'-ethyl-2-methyl-3-piperidino-propiophenone
EMPP
eperisone
MFCD00867679
Eperisone HCl

Biological Activity

[Description]:

Eperisone is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a vasodilator effect[1][2 [3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Cabitza P, et al. Efficacy and safety of eperisone in patients with low back pain: a double blind randomized study. Eur Rev Med Pharmacol Sci. 2008 Jul-Aug;12(4):229-35.

[2]. Frandisco Colomer Rusinvol, et al. Effects of Two Diffferent Doses of Eperisone in the Treatment of Acute Low Back Pain. The Journal of Applied Research.

[3]. Bavage S, et al. Clinical efficacy and safety of eperisone for low back pain: A systematic literature review. Pharmacol Rep. 2016 Oct;68(5):903-12.

Chemical & Physical Properties

[ Density]:
0.994 g/cm3

[ Boiling Point ]:
386.8ºC at 760 mmHg

[ Melting Point ]:
170-172ºC

[ Molecular Formula ]:
C₁₇H₂₅NO

[ Molecular Weight ]:
259.38600

[ Flash Point ]:
137.4ºC

[ Exact Mass ]:
259.19400

[ PSA ]:
20.31000

[ LogP ]:
3.49160

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UC2022000

CHEMICAL NAME :: 1-Propanone, 1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-

CAS REGISTRY NUMBER :: 64840-90-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H25-N-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 4550 mg/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in adrenal weight

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 20,1027,1992

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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