64840-90-0

64840-90-0 structure

Name: Eperisone
Chemical Name: 1-(4-ethylphenyl)-2-methyl-3-piperidin-1-ylpropan-1-one
CAS Number: 64840-90-0
Molecular Formula: C₁₇H₂₅NO
Molecular Weight: 259.38600
Catalog: API Anesthetic Agents Skeletal muscle relaxant
Create Date: 2018-04-18 08:00:00
Modify Date: 2024-01-04 12:20:45
Eperisone is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a vasodilator effect[1][2 [3].

Name	1-(4-ethylphenyl)-2-methyl-3-piperidin-1-ylpropan-1-one
Synonyms	4-ethylphenyl-2-methyl-3-piperidinopropiopenone 4'-ethyl-2-methyl-3-piperidino-propiophenone EMPP eperisone MFCD00867679 Eperisone HCl

Description	Eperisone is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a vasodilator effect[1][2 [3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Cabitza P, et al. Efficacy and safety of eperisone in patients with low back pain: a double blind randomized study. Eur Rev Med Pharmacol Sci. 2008 Jul-Aug;12(4):229-35. [2]. Frandisco Colomer Rusinvol, et al. Effects of Two Diffferent Doses of Eperisone in the Treatment of Acute Low Back Pain. The Journal of Applied Research. [3]. Bavage S, et al. Clinical efficacy and safety of eperisone for low back pain: A systematic literature review. Pharmacol Rep. 2016 Oct;68(5):903-12.

Density	0.994 g/cm3
Boiling Point	386.8ºC at 760 mmHg
Melting Point	170-172ºC
Molecular Formula	C₁₇H₂₅NO
Molecular Weight	259.38600
Flash Point	137.4ºC
Exact Mass	259.19400
PSA	20.31000
LogP	3.49160

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UC2022000

CHEMICAL NAME :: 1-Propanone, 1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-

CAS REGISTRY NUMBER :: 64840-90-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H25-N-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 4550 mg/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in adrenal weight

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 20,1027,1992

HS Code	2933399090

56839-43-1

~78%

64840-90-0

Literature: BIONEVIA PHARMACEUTICALS, INC.; KALOFONOS, Isabel; STAHLY, G., Patrick; MARTIN-DOYLE, William; KALOFONOS, Dimitris; STULTS, Jeffrey, S.; HANKO, Jason, A. Patent: WO2010/81070 A2, 2010 ; Location in patent: Page/Page column 33 ;

Precursor 1
56839-43-1
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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