trans-4-Carboxy-L-proline

Names

[ Name ]:
trans-4-Carboxy-L-proline

[Synonym ]:
L-trans-pyrrolidine-2,4-dicarboxylic acid
MFCD00153866
Quipazine dimaleate
trans-4-Carboxy-L-proline
t-2,4-PDC
L-trans-PDC
t-PDC

Biological Activity

[Description]:

Trans-4-Carboxy-L-prolineis a selective glutamate transporter inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Bridges RJ, et al. Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. J Med Chem. 1991 Feb;34(2):717-25.

Chemical & Physical Properties

[ Density]:
1.456 g/cm3

[ Boiling Point ]:
355.3ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₉NO₄

[ Molecular Weight ]:
159.14000

[ Flash Point ]:
168.7ºC

[ Exact Mass ]:
159.05300

[ PSA ]:
86.63000

[ Index of Refraction ]:
1.534

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Evidence for a role of GABA- and glutamate-gated chloride channels in olfactory memory.

Pharmacol. Biochem. Behav. 103(1) , 69-75, (2012)

In the honeybee, we investigated the role of transmissions mediated by GABA-gated chloride channels and glutamate-gated chloride channels (GluCls) of the mushroom bodies (MBs) on olfactory learning us...

Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors.

Bioorg. Med. Chem. Lett. 16(12) , 3268-72, (2006)

A series of substituted pyrrolidine-2,4-dicarboxylic acid amides were synthesized as potential antidiabetic agents, and many of them showed good in vitro DPP-IV inhibition (IC50 = 2-250 nM) with selec...

The effects of local perfusion of DAMGO on extracellular GABA and glutamate concentrations in the rostral ventromedial medulla.

J. Neurochem. 104(3) , 806-17, (2008)

Electrophysiological data suggest an involvement of rostral ventromedial medulla (RVM) GABA and glutamate (GLU) neurons in morphine analgesia. Direct evidence that extracellular concentrations of GABA...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.