Malvidin chloride

Names

[ CAS No. ]:
643-84-5

[ Name ]:
Malvidin chloride

[Synonym ]:
MFCD00017585
2-(4-hydroxy-3,5-dimethoxyphenyl)chromenylium-3,5,7-triol,chloride
EINECS 211-403-8

Biological Activity

[Description]:

Malvidin (chloride) is a bioactive compound isolated from Oryza sativacv. Heugjinjubyeo. Malvidin shows cytotoxicity through the arrest of the G2/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Malvidin (0~80 μg/mL; 96 hours; U937 cells) shows cytotoxic activity in a dose-dependent pattern[1]. The IC50 value of Malvidin for U937 cells is 40 μg/mL. Malvidin (U937 cells) shows arrest at the G2/M phase of the cell cycle and increases sub G1 hypo-diploid population[1]. Cell Viability Assay[1] Cell Line: U937 cells Concentration: 0~80 μg/mL Incubation Time: 96 hours Result: Showed cytotoxic activity in a dose-dependent pattern.

[References]

[1]. Jin W H, et al. Cyanidin and Malvidin fromOryza sativacv. HeugjinjubyeoMediate Cytotoxicity against Human Monocytic Leukemia Cellsby Arrest of G2/M Phase and Induction of Apoptosis. J. Agric. Food Chem. 2004, 52, 8, 2213–2217

Chemical & Physical Properties

[ Density]:
1.183 g/mL at 25 °C(lit.)

[ Boiling Point ]:
66-67 °C(lit.)

[ Molecular Formula ]:
C₁₇H₁₅ClO₇

[ Molecular Weight ]:
366.75000

[ Flash Point ]:
30 °F

[ Exact Mass ]:
366.05100

[ PSA ]:
112.52000

[ LogP ]:
0.22450

[ Index of Refraction ]:
n20/D 1.335(lit.)

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK9900000

CHEMICAL NAME :: Flavylium, 3,4',5,7-tetrahydroxy-3',5'-dimethoxy-, chloride

CAS REGISTRY NUMBER :: 643-84-5

LAST UPDATED :: 198912

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H15-O7.Cl

MOLECULAR WEIGHT :: 366.77

WISWESSER LINE NOTATION :: T66 BOJ CR DQ CO1 EO1& DQ GQ IQ &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01634 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: male 60 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 57,1354,1988

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LK9900000

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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