1Alphah,5alphah-tropan-3alpha-ol (+-)-tripate (ester), hydrobromide

Names

[ Name ]:
1Alphah,5alphah-tropan-3alpha-ol (+-)-tripate (ester), hydrobromide

Biological Activity

[Description]:

Atropine (Tropine tropate) hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[Target]

IC50: 0.39 nM (Human mAChR M4) and 0.71 nM (Chicken mAChR M4)[3]

[In Vitro]

Atropine (Tropine tropate; 1 μM; pulmonary veins and arteries) hydrobromide inhibits ACh-induced relaxations in human pulmonary veins[4].

[In Vivo]

Atropine (Tropine tropate; 10 mg/kg; i.p.; once, for 40 minutes; Peromyscus sp.) hydrobromide inhibits the cardiac arrhythmia which normally occurs throughout torpor[2]. Animal Model: White-footed mice (Peromyscus sp.)[2] Dosage: 10 mg/kg Administration: Intraperitoneal injection; once, for 40 minutes Result: Increased heart rate was a decrease in cardiac arrhythmia.

[References]

[1]. McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33(3):373-8.

[2]. Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33(2):441-57.

[3]. Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791.

[4]. Walch L, et, al. Evidence for a M(1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130(1):73-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₄BrNO₃

[ Molecular Weight ]:
370.28100

[ Exact Mass ]:
369.09400

[ PSA ]:
49.77000

[ LogP ]:
2.82690

Precursor & DownStream

Precursor

DownStream

Related Compounds

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