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2,6-Diamino-9-(2-C-Methyl-β-D-ribofuranosyl)-9H-purine

Names

[ CAS No. ]:
640725-73-1

[ Name ]:
2,6-Diamino-9-(2-C-Methyl-β-D-ribofuranosyl)-9H-purine

[Synonym ]:
MFCD25542527
Adenosine, 2-amino-2'-C-methyl-
2-Amino-2'-C-methyladenosine

Biological Activity

[Description]:

2-Amino-2′-C-methyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
754.6±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H16N6O4

[ Molecular Weight ]:
296.28

[ Flash Point ]:
410.2±35.7 °C

[ Exact Mass ]:
296.123291

[ LogP ]:
0.49

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.883

Related Compounds