VUF 5681 dihydrobromide

Names

[ Name ]:
VUF 5681 dihydrobromide

[Synonym ]:
Pentoxyresorufin
VUF 5681 dihydrobromide

Biological Activity

[Description]:

VUF 5681 dihydrobromide is a neutral antagonist of histamine H3 receptor. VUF 5681 dihydrobromide also has partial agonist function of H3 receptor. VUF 5681 dihydrobromide blocks the effects of Thioperamide (HY-12206). VUF 5681 dihydrobromide is used in central nervous system disease research[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

H3 receptor

[References]

[1]. Moreno-Delgado D, et al. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology. 2006 Sep;51(3):517-23.

[2]. Baker JG. Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. BMC Pharmacol. 2008 Jun 6;8:9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₂₁Br₂N₃

[ Molecular Weight ]:
355.11

[ Exact Mass ]:
353.01000

[ PSA ]:
40.71000

[ LogP ]:
3.97700

Related Compounds

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