BULBOCAPNINE HYDROCHLORIDE

Names

[ CAS No. ]:
632-47-3

[ Name ]:
BULBOCAPNINE HYDROCHLORIDE

[Synonym ]:
N-METHYLLAUNOBINE HYDROCHLORIDE
MFCD00069363
EINECS 211-178-6
BULBOCAPNINE HCL
Buibocapnine hydrochloride

Biological Activity

[Description]:

Bulbocapnine hydrochloride, an aporphine alkaloid, is a dopamine receptor inhibitor. Bulbocapnine hydrochloride inhibits dopamine synthesis. Bulbocapnine hydrochloride also has neuroleptic-like, anticonvulsant and antinociceptive effects[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Shin JS, et al. Inhibitory effects of bulbocapnine on dopamine biosynthesis in PC12 cells. Neurosci Lett. 1998 Mar 20;244(3):161-4.

[2]. Zetler G. Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: bulbocapnine, corytuberine, boldine and glaucine. Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:255-81.

[3]. Kohli JD,et al. Bulbocapnine is not a selective DA1 receptor antagonist. J Pharm Pharmacol. 1986 May;38(5):401-2.

Chemical & Physical Properties

[ Boiling Point ]:
504ºC at 760 mmHg

[ Melting Point ]:
209-210ºC

[ Molecular Formula ]:
C₁₉H₂₀ClNO₄

[ Molecular Weight ]:
361.82

[ Flash Point ]:
258.6ºC

[ Exact Mass ]:
361.10800

[ PSA ]:
51.16000

[ LogP ]:
3.62150

[ Appearance of Characters ]:
solid | tan

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CE1054000

CHEMICAL NAME :: 6a-alpha-Aporphin-11-ol, 10-methoxy-1,2-(methylenedioxy)-, hydrochloride

CAS REGISTRY NUMBER :: 632-47-3

LAST UPDATED :: 199012

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H19-N-O4.Cl-H

MOLECULAR WEIGHT :: 361.85

WISWESSER LINE NOTATION :: T D56 J666 1A T EO GO RN FH&&&TTJ KQ LO1 R1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 236,149,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 31,27,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 137,375,1962

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CE1054000