XL-844

Names

[ Name ]:
XL-844

Biological Activity

[Description]:

A potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively; increases gemcitabine-induced H2AX phosphorylation, blocks Cdc25A phosphorylation, and induces premature mitotic entry; significantly enhances gemcitabine antitumor activity in a PANC-1 xenograft model. Blood Cancer Phase 1 Discontinued

[References]

References 1. Riesterer O, et al. Invest New Drugs. 2011 Jun;29(3):514-22. 2. Matthews DJ, et al. Cell Cycle. 2007 Jan 1;6(1):104-10. View Related Products by Target Checkpoint Kinase (Chk) Blood Cancer

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₇N₅O₂

[ Molecular Weight ]:
287.323

Related Compounds

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