XL-281

Names

[ Name ]:
XL-281

[Synonym ]:
UNII:DW2NWI3TFN
Methyl {5-[2-(5-chloro-2-methylphenyl)-1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1H-benzimidazol-2-yl}carbamate
BMS-908662
Carbamic acid, N-[5-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester
DW2NWI3TFN

Biological Activity

[Description]:

XL-281 (BMS 908662) is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models; demonstrates biological activity by modulation of the RAF pathway in tumor and surrogate tissue, with decreases in cell proliferation and increases in apoptosis. Colon Cancer Phase 2 Discontinued

[References]

References 1. Callahan MK, et al. Cancer Immunol Res. 2014 Jan;2(1):70-9. 2. Belum VR, et al. Cancer. 2015 Jan 1;121(1):60-8. 3. Dickson MA, et al. Invest New Drugs. 2015 Apr;33(2):349-56. View Related Products by Target Raf Colon Cancer

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₂₄H₁₉ClN₄O₄

[ Molecular Weight ]:
462.885

[ Exact Mass ]:
462.109497

[ LogP ]:
5.03

[ Index of Refraction ]:
1.754

Related Compounds

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