NSC45586

Names

[ Name ]:
NSC45586

Biological Activity

[Description]:

NSC45586 sodium is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 sodium targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Jackson TC, et, al. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28.

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Boiling Point ]:
675.7ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₁₇N₆NaO₃

[ Molecular Weight ]:
412.38

[ Flash Point ]:
362.5ºC

[ Exact Mass ]:
413.13400

[ PSA ]:
159.01000

[ LogP ]:
6.55640

[ Index of Refraction ]:
1.702

[ Storage condition ]:
-20°C

Related Compounds

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