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gomisin G

Names

[ CAS No. ]:
62956-48-3

[ Name ]:
gomisin G

[Synonym ]:
(6S,7S,8S)-7-Hydroxy-1,2,3,13-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-8-yl benzoate
UNII:6B4CV8T31X
Benzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole-7,8-diol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, 8-benzoate, (6S,7S,8S)-
The dried fruit of Schisandra chinensis

Biological Activity

[Description]:

Gomisin G is an ethanolic extract of the stems of Kadsura interior; exhibits potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 microgram/mL and 300, respectively.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Natural Products >> Phenylpropanoids
Research Areas >> Infection

[References]

[1]. Chen DF, et al. Anti-AIDS agents--XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues. Bioorg Med Chem. 1997 Aug;5(8):1715-23.

[2]. Ikeya Y, et al. The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin. Chem Pharm Bull (Tokyo). 1979 Jun;27(6):1383-94.


[Related Small Molecules]

Cenicriviroc | Ebselen | Triciribine | Raltegravir (potassium salt) | Tipranavir | DELAVIRDINE MESYLATE | Bictegravir | TAK-779 | Betulinic acid | Nelfinavir mesylate | Cabotegravir | nevirapine | Zidovudine | Celgosivir (hydrochloride)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
670.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H32O9

[ Molecular Weight ]:
536.570

[ Flash Point ]:
217.2±25.0 °C

[ Exact Mass ]:
536.204651

[ PSA ]:
101.91000

[ LogP ]:
6.38

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.623

[ Storage condition ]:
2-8℃

Related Compounds