6-chlorohexyl bromide

Names

[ Name ]:
6-chlorohexyl bromide

[Synonym ]:
MFCD00001019
1-Bromo-6-chlorohexane
Cl(CH2)6-Br
1-Chloro-6-bromohexane
Hexane, 1-bromo-6-chloro-
1-bromo-6-chloro-hexane
6-chlorohexyl bromide
Hexyl bromide, 6-chloro-
EINECS 228-555-6
1,6-bromochlorohexane
Hexyl bromide,6-chloro
Hexane,1-bromo-6-chloro
6-Bromohexyl Chloride
1-bromo-6-chloro-n-hexane
1-bromo-6-chlorobutane

Biological Activity

[Description]:

1-Bromo-6-chlorohexane is a PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> PROTAC >> PROTAC Linker

[References]

[1]. Sun D, Nikonova AS, Zhang P, Deneka AY, Fitzgerald ME, Michael RE, Lee L, Lilly AC, Fisher SL, Phillips AJ, Nasveschuk CG, Proia DA, Tu Z, Golemis EA. Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models. Mol Cancer Ther. 2021 Aug;20(8):1367-1377.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
217.4±8.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₁₂BrCl

[ Molecular Weight ]:
199.52

[ Flash Point ]:
101.1±0.0 °C

[ Exact Mass ]:
197.981079

[ LogP ]:
3.49

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.470

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S23-S24/25

[ RIDADR ]:
2810

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Preparation of highly functionalized alkylzinc halides from alkyl bromides using Mg, ZnCl2 and LiCl.

Chem. Commun. (Camb.) 46(23) , 4082-4, (2010)

Alkyl bromides bearing various functional groups are smoothly converted to functionalized alkylzinc reagents by the direct insertion of magnesium in the presence of LiCl and ZnCl(2).