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TP 003

Names

[ CAS No. ]:
628690-75-5

[ Name ]:
TP 003

Biological Activity

[Description]:

TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. Elena Neumann, et al. TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors. Neuropharmacology. 2018 Dec;143:71-78.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H16F3N3O

[ Molecular Weight ]:
407.38800

[ Exact Mass ]:
407.12500

[ PSA ]:
61.32000

[ LogP ]:
5.18468

Related Compounds