Rac1-IN-1
Names
[ CAS No. ]:
627042-19-7
[ Name ]:
Rac1-IN-1
Biological Activity
[Description]:
A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM; diminishes the EGF-induced Rac1 activation in CD18/HPAF cells with EC50 of 8.3±1.7 uM, has no inhibitory effect on either Cdc42 or RhoA in CD18/HPAF cells; shows a 50% and 20% decrease in proliferation for AsPC-1 and CD18/HPAF cells at 25 uM; also reduces migration of pancreatic cancer cells.
[References]
References 1. Arnst JL, et al. Oncotarget. 2017 May 23;8(21):34586-34600. View Related Products by Target Small GTPase
Chemical & Physical Properties
[ Molecular Formula ]:
C19H14N2O5
[ Molecular Weight ]:
350.33