Rac1-IN-6
Names
[ CAS No. ]:
701223-06-5
[ Name ]:
Rac1-IN-6
Biological Activity
[Description]:
A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 88±48 nM; diminishes the EGF-induced Rac1 activation in CD18/HPAF cells with EC50 of 22.4±3.2 uM, has no inhibitory effect on either Cdc42 or RhoA in CD18/HPAF cells; inhibits the proliferation, reduces migration of pancreatic cancer cells.
[References]
References 1. Arnst JL, et al. Oncotarget. 2017 May 23;8(21):34586-34600. View Related Products by Target Small GTPase
Chemical & Physical Properties
[ Molecular Formula ]:
C23H20N2O2S
[ Molecular Weight ]:
388.485