formohydrazide
Names
[ CAS No. ]:
624-84-0
[ Name ]:
formohydrazide
[Synonym ]:
MFCD00007589
Formic hydrazide
formohydrazide
formic acid hydrazide
Hydrazine, formyl-
EINECS 210-867-9
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
129.7±23.0 °C at 760 mmHg
[ Melting Point ]:
52-57 °C(lit.)
[ Molecular Formula ]:
CH4N2O
[ Molecular Weight ]:
60.055
[ Flash Point ]:
32.2±22.6 °C
[ Exact Mass ]:
60.032364
[ PSA ]:
55.12000
[ LogP ]:
-2.05
[ Vapour Pressure ]:
10.0±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.424
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
Soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LQ8615000
- CHEMICAL NAME :
- Formic acid, hydrazide
- CAS REGISTRY NUMBER :
- 624-84-0
- BEILSTEIN REFERENCE NO. :
- 0635759
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C-H4-N2-O
- MOLECULAR WEIGHT :
- 60.07
- WISWESSER LINE NOTATION :
- ZMVH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,645,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 4,259,1961 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 73 gm/kg/43W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- REFERENCE :
- BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 37,960,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4064 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 919 (estimated) No. of Female Employees: 306 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R20/21/22;R36/37/38
[ Safety Phrases ]:
S26-S36-S36/37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
LQ8615000
[ HS Code ]:
2928000090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2928000090
[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
Articles
Carcinogenesis 1(1) , 61-5, (1980)
N-ethyl-N-formylhydrazine (EFH) was administered as a 0.02% solution in drinking water continuously for life to randomly bred Swiss mice, from 6 weeks of age. The treatment induced tumors of the lungs...
Traceless liquid-phase synthesis of 3-alkylamino-4, 5-disubstituted-1, 2, 4-triazoles on polyethylene glycol (PEG). Zong Y-X, et al.Tetrahedron Lett. 46(31) , 5139-41, (2005)
Synthesis of NB-506, a new anticancer agent. Ohkubo M, et al.
Tetrahedron 53(2) , 585-92, (1997)