1,3-DINITROGLYCERIN

Names

[ CAS No. ]:
623-87-0

[ Name ]:
1,3-DINITROGLYCERIN

[Synonym ]:
1,3-di-O-nitroglycerol
(2-hydroxy-3-nitrooxypropyl) nitrate
1,3-Dinitroglycerin
1,3-Dng
glycerine 1,3-dinitrate
1,3-Dinitroglycerol
1,2,3-propanetriol 1,3-dinitrate
1,3-Glyceryl dinitrate
Glycerol-1,3-dinitrate
Glyceryl-1,3-dinitrate
1,3-dinitroxy-2-hydoxypropane

Chemical & Physical Properties

[ Density]:
1.594 g/cm3

[ Boiling Point ]:
170.2ºC at 760 mmHg

[ Melting Point ]:
26°C

[ Molecular Formula ]:
C₃H₆N₂O₇

[ Molecular Weight ]:
182.08900

[ Flash Point ]:
56.8ºC

[ Exact Mass ]:
182.01800

[ PSA ]:
130.33000

[ Index of Refraction ]:
1.489

[ Storage condition ]:
?20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA9487500

CHEMICAL NAME :: Glycerol, 1,3-dinitrate

CAS REGISTRY NUMBER :: 623-87-0

BEILSTEIN REFERENCE NO. :: 1784163

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C3-H6-N2-O7

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1065 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-B011-150

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 676 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-B011-150

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H312 + H332-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338

[ Hazard Codes ]:
F,Xn

[ Risk Phrases ]:
11-20/21/22-36

[ Safety Phrases ]:
16-36/37

[ RIDADR ]:
0473

[ Packaging Group ]:
II

[ Hazard Class ]:
1.1A

[ HS Code ]:
2920909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2920909090

[ Summary ]:
2920909090 esters of other inorganic acids of non-metals (excluding esters of hydrogen halides) and their salts; their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Biotransformation of glyceryl trinitrate by rat brain homogenate.

Can. J. Physiol. Pharmacol. 70(6) , 935-7, (1992)

Incubation of glyceryl trinitrate (GTN) with 5% (w/v) rat brain homogenate (RBH) resulted in biotransformation of the organic nitrate vasodilator drug to a mixture of glyceryl-1,2-dinitrate (1,2-GDN) ...

Effect of temperature on glyceryl trinitrate induced relaxation of rabbit aorta.

Can. J. Physiol. Pharmacol. 71(8) , 629-32, (1993)

It has previously been shown that the vasodilatory response to glyceryl trinitrate (GTN) was decreased during hypothermic cardiopulmonary bypass. The purpose of these experiments was to determine the ...

Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: a preliminary report.

J. Pharmacokinet. Biopharm. 21(2) , 163-73, (1993)

Studies were carried out in conscious dogs to determine the effects of 1,2-glyceryl dinitrate (1,2-GDN) and 1,3-glyceryl dinitrate (1,3-GDN) on nitroglycerin (GTN) pharmacokinetics and pharmacodynamic...